Sonic Cholesterol

Sonic CholesterolNew Beginnings Nutritionals would like to announce a new product called Sonic Cholesterol which is a pure and potent nutritional supplement designed to correct cholesterol deficiency.  Recent scientific research has shown that a high percentage of individuals with autism have low cholesterol levels.  Cholesterol deficiency is also associated with drug addiction, cancer, violent behavior, aggression, anxiety, depression, bipolar disorder, suicide, strokes, cataracts and increased susceptibility to gastrointestinal infections. Sonic Cholesterol is and ideal supplement solution for children and adults who have both low to low normal cholesterol levels along with a strong dislike for - or allergy to - eggs. 

Product Description:

  • Each capsule contains 250 mg of pure medical grade cholesterol

  • Each 250 mg dose provides the same amount of cholesterol as one egg

  • Carefully extracted from raw sheep wool

  • Tested and shows undetectable levels of heavy metals and other toxic chemicals

  • Available only to those under the care of a physician

Dosage Recommendations:

For very low cholesterol values (<100 mg/dl)
Dose 4-6 capsules (1000 - 1500 mg) per day in divided doses with meals.
For moderately low cholesterol values (100 to 130 mg/dl):
Dose 3-4 capsules (750-1000 mg) per day in divided doses with meals.
For low normal cholesterol values (130 to 160 mg/dl):
Dose 2 capsule per day (500 mg) in divided doses with meals.

Precautions:  Monthly cholesterol testing is strongly recommended for a time to monitor and adjust cholesterol dosing until blood levels are stabilized. Please visit www.gpl4u.com for more information about testing.

Retail Price:     $32.00, 120 capsules

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease
     

Benefits of cholesterol in the diet

Every day supplementation with high cholesterol foods, such as egg yolks, might prove to be a useful therapy to try for a few months for children with autism who have cholesterol values that are low (<160 mg/dL).  Unfortunately egg allergy is common in autism and may increase with a steady egg diet and compliance may be difficult for children who dislike eggs. Although very high blood serum cholesterol values are associated with heart disease, values that are low (below 160 mg/dl) are associated with increased violent behavior, suicide, depression, anxiety, bipolar disease, Parkinson’s disease, and increased mortality from cancer. Surprisingly, high cholesterol protects against some infectious diseases like tuberculosis, which has been uncommon in the USA since The Great Depression, during which Benefits of cholesterol in the dietthere was a substantial lack of high cholesterol foods because of financial hardship. Vegetarians have a much higher incidence of tuberculosis than meat eaters. It is possible that the overemphasis on a low cholesterol diet may also be associated with the recent marked increase in cases of tuberculosis. Low cholesterol values are also associated with manganese deficiency, celiac disease, hyperthyroidism, liver disease, malabsorption, and malnutrition. Pregnant women with low cholesterol are twice as likely to have premature babies or babies with small heads.

LDL cholesterol (so-called bad cholesterol) protects humans against infection. Deadly staphylococcus bacteria produce endotoxins that have the ability to kill human cells including red blood cells. LDL was found to protect human red blood cells from this toxic effect of endotoxin while HDL was not protective. A study at the University of Pittsburgh found that in young and middle aged men, those that had LDL-cholesterol below 160 mg/dl had a significantly lower number (of total and various types) of white blood cells than men with LDL-cholesterol above 160 mg/l.

Functions of Sonic Hedgehog (SHH):
  • Plays a central role in developmental patterning, especially of the nervous system and the skeletal system.

  • Important in the growth and differentiation of a variety of cell types, including the development of T cells in the thymus.

  • Purkinje neurons secrete SHH to sustain the division of granule neuron precursors in the external granule layer in cerebral development. Abnormal cerebellar development and especially purkinje cell development has been associated with autism.

  • As a transcription regulating protein, SHH alters which genes function at a given time.

Testing for cholesterol, cholesterol transport proteins, and homocysteine at The Great Plains Laboratory

Cholesterol testingThe Great Plains Laboratory has developed a special cholesterol related panel that will help to determine whether cholesterol deficiency or abnormalities in cholesterol transport are present.  This panel will include the following markers: Total cholesterol, apolipoprotein A-1, apolipoprotein B, Lipoprotein (a), and homocysteine. Lipoproteins are involved in cholesterol, lipid, and vitamin E transport.

Total cholesterol: Total cholesterol measures all types of cholesterol including esterified and free. Low values (generally values less than 160 mg/dL) are associated with genetic diseases of cholesterol metabolism such as SLOS, Tangier’s disease, and abetalipoproteinemia. Low values are more common in hyperthyroidism, liver disease, malabsorption, malnutrition, autism, violent behavior, celiac disease, anxiety, bipolar disease, alcoholism, lung cancer, suicide, depression, and obesity associated with human adenovirus-36 infection. In China, where mean cholesterol is much lower than in the Western world, chronic hepatitis B virus infection is ubiquitous. Chronic carriers of hepatitis B, but not individuals with eradicated hepatitis B, have significantly lower total cholesterol than non-carriers, suggesting a cause-effect relationship. High cholesterol values are associated with atherosclerosis.

Apolipoprotein A-I (Apo A-1): The main protein component of HDL (high density lipoprotein). It accounts for approximately 65% of the total protein content of HDL. Apo A-I activates lecithin cholesterol acyltransferase which catalyses the esterification of cholesterol. The resulting esterified cholesterol can then be transported to the liver, metabolized and excreted. Values of Apo A-I have been shown to decrease during infection.

 

Apolipoprotein B (Apo B): The main protein component of LDL (low density lipoprotein). It accounts for approximately 95% of the total protein content of LDL. Apolipoprotein B is necessary for the reaction with LDL receptors in the liver and on cell walls and is thus involved in transporting cholesterol from the liver to the cells. Recently the Mind Institute found that low values of Apo B are associated with autism, with the lowest values being found in low-functioning autism. LDL has found to have protective effects against endotoxins from deadly staphylococcus.

Lipoprotein (a): Consists of two components, the low-density lipoprotein (LDL) and a glycoprotein, which are linked by a disulfide bridge.  High values have been implicated as a risk factor for cardiovascular disease, Alzheimer’s disease,Crohn’s disease, and rheumatoid arthritis. Low values have also been found in those with autism who have higher doses of Apolipoprotein E epsilon-4 gene variants that are associated with increased risk of Alzheimer’s disease. Lipoprotein (a) is biochemically unrelated to Apolipoprotein A.

Homocysteine: A sulfur-containing amino acid that can be converted to methionine by methionine synthetase or by betaine methyl transferase. The role of homocysteine in atherosclerosis gained attention after finding massive atherosclerosis in young people with the genetic disorder homocystinuria. Methionine synthetase requires the folic acid derivative 5-methyl tetrahydrofolate. Abnormally high values have been reported in stroke, cardiovascular disease, and in Alzheimer’s disease. Both low and high values have been reported in autism.

All of the Great Plains testing for the cholesterol panel is done with FDA-approved diagnostic laboratory reagents.

 

 

Why the brain needs cholesterol

  • There is a direct correlation between the concentration of cholesterol in the brain, particularly in the myelin, and how well the brain functions.

  • The brain is the most cholesterol-rich organ in the body.

  • In the central nervous system (CNS), essentially all (99.5%) cholesterol is the free or unesterified form (unattached to fatty acids).

  • The majority (70%) of cholesterol present in the CNS is believed to reside in the myelin (the material that insulates the nerve fibers) sheaths and the plasma membranes of astrocytes (brain support cells) and neurons.

  • Half of the white matter, which contains the nerve axons that allow for transmission of brain signals, may be composed of cholesterol-rich myelin.

Helpful links
References

1. E Tierney, I Bukelis, R Thompson, K Ahmed, A Aneja, L Kratz, and R Kelley. Abnormalities of Cholesterol Metabolism in Autism Spectrum Disorders. American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 141B:666–668 (2006). http://www.ncbi.nlm.nih.gov/pubmed/16874769

2. Tierney E, Nwokoro NA, Kelley RI Behavioral phenotype of RSH/Smith-Lemli-Opitz syndrome. Ment Retard Dev Disabil Res Rev 2000;6(2):131-4.  http://www.ncbi.nlm.nih.gov/pubmed/10899806
 
3. Sikora DM, Pettit-Kekel K, Penfield J, Merkens LS, Steiner RD. The near universal presence of autism spectrum disorders in children with Smith-Lemli-Opitz syndrome. Am J Med Genet A. 2006 Jul 15;140(14):1511-8. http://www.ncbi.nlm.nih.gov/pubmed/16761297

4. Modai I et al. Serum cholesterol levels and suicidal tendencies in psychiatric inpatients. J Clin Psychiatry. 1994 Jun;55(6):252-4. http://www.ncbi.nlm.nih.gov/pubmed/8071280

5. Cassidy F, Carroll BJ. Hypocholesterolemia during mixed manic episodes. Eur Arch Psychiatry Clin Neurosci. 2002 Jun;252(3):110-4. http://www.ncbi.nlm.nih.gov/pubmed/12192467

6. Perez-Guzman C, Vargas, MH, Quinonez, F, et al. A cholesterol-rich diet accelerates bacteriologic sterilization in pulmonary tuberculosis. Chest 2005; 127: 643-651. http://www.ncbi.nlm.nih.gov/pubmed/15706008

7. Glueck CJ, et al Hypocholesterolemia, hypertriglyceridemia, suicide, and suicide ideation in children hospitalized for psychiatric diseases. Pediatr Res. 1994 May;35(5):602-10. http://www.ncbi.nlm.nih.gov/pubmed/8065845

8. 17:00 22 January 2007, NewScientist.com news service, Aria Pearson, http://www.newscientist.com/article/dn11005-protecting-fetuses-from-mothers-who-drink.html